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Bredereck Reagent
N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL
Favipiravir
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Pno:LCBD-00001 
Product Name:Bredereck’s Reagent 
Synonyms:Tert-Butoxy-bis(dimethyamino)-methane 
Cas No.:5815-08-7 
Molecular Formula:174.28 
Molecular Weight:C9H22N2O 
Assay:90% 
Molecular Structure: 
概要 tert-Butoxy-bis(dimethylamino)methane通常被叫做Bredereck试剂、该试剂用于羰基的α-烯次甲基胺基化反应。   基本文献 Bredereck, H.; Simchen, G.; Rebsdat, S.; Kantlehner, W.; Horn, P.;Wahl, R.; Hoffmann, H.; Grieshaber, P. Chem. Ber. 1968, 101, 41.  Kantlehner, W.; Speh, P. Chem. Ber. 1972, 105, 1340. Review  Kantlehner, W.; Prakt. J. Chem. Chem.-Ztg. 1995, 337, 418.   反应机理 反应体系中生成了关键的强碱性的tBuO–,拔去酸性相对较高的羰基α-H, 从而实现methylene化反应。
    反应实例 吲哚合成
    实验步骤 基本上该反应在THF或二氧六环这类醚类溶液中加热进行反应即可。   实验技巧   参考文献 Trost, B. M.; Preckel, M. J. Am. Chem. Soc. 1973, 95, 7862. DOI: 10.1021/ja00804a051 Haefliger, W. Knecht, H.  Tetrahedron Lett. 1983, 25, 285. DOI: 10.1016/S0040-4039(00)99863-0 Vors, J.-P.; J. Heterocycl. Chem. 1991, 28, 1043  Spivey A. C. et al., J. Org. Chem. 2000, 65, 5253. DOI: 10.1021/jo000401x  Morera E. et al., Org. Lett. 2002, 4, 1139. DOI: 10.1021/ol0255458 Csihony, S. et al., Adv. Synth. Catal. 2004, 346, 1081.  DOI: 10.1002/adsc.200404097 
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